1,6-Conjugate Addition of n-Butyllithium to para-Quinone Methides: An Access to Diarylmethanes.

Abstract

An efficient method for the synthesis of alkyl diarylmethanes through the 1,6-conjugate addition of n-BuLi reagent to paraquinone methides (p-QMs) has been developed here with mild conditions and short reaction period. This protocol allows to access unsymmetrical alkyl diarylmethanes in moderate to excellent yields using a wide range of p-QMs and n-Butyllithium reagent.