Studies on the Ni-Catalyzed Synthesis of Tertiary Amides and Pd-Catalyzed Synthesis of α- Naphthol-Based Triarylmethanes, Ortho-Arylated D-(-)-Phenylglycine Methyl Esters and β-Arylated Keto Acids

Abstract

This thesis entitled “Studies on the Ni-Catalyzed Synthesis of Tertiary Amides and Pd- Catalyzed Synthesis of α-Naphthol-Based Triarylmethanes, Ortho-Arylated D-(-)- Phenylglycine Methyl Esters and β-Arylated Keto Acids” deals on (a) the construction of tertiary amides via the Ni(II)-catalyzed N-arylation of secondary acyclic amides (2- picolinamides) with aryl halides, (b) palladium-catalyzed desulfitative Heck reaction and synthesis of α-naphthol-based triarylmethanes, (c) palladium-catalyzed ortho-arylation of D- (-)-2-phenylglycine methyl ester using bidentate picolinamide directing group and (d) palladium-catalyzed bidentate ligand directed β-C(sp 3 )-H functionalization on ε-, ζ-, η-keto acids.