Regulation of Protocadherin-15 in Glioma Progression

Abstract

Due to high mortality rate around the world glioma is a hot topic for cancer researchers. Although Lower grade glioma (LGG) and Glioblastoma Multiforme (GBM) are glial cell cancer, their mode of progression and survival rate is significantly different than each other. To understand their mode of progression, it is important to study these gliomas at molecular level. In this thesis we show how Protocadherin-15, a non-classical cadherin family protein, is differentially expresses between LGG and GBM tumors. We also highlighted how its expression is regulated at genomic and epigenetic level.