Access to Naphthalene Derivatives from 2-Alkeny1-pheny1- substituted para-quinone methodes

Abstract

A base-mediated and Lewis acid catalyzed one-pot reaction between 2-alkenylphenyl- substituted p-quinone methides and bromo-malonates has been developed to access a wide range of naphthalene derivatives. Basically, this transformation involves two different steps, i.e., (i) base-mediated cyclopropanation of 2-alkenylphenyl-substituted p-quinone methides with bromo-malonates (ii) Lewis acid catalyzed intramolecular annulation of cyclopropenyl- alkenes to form the naphthalene derivatives.