Comparative structural studies of peptide transporters and their roles in physiological processes

Abstract

The POT family of membrane transporter proteins shows remarkable feature of diverse substrate promiscuity. This promiscuity has led to development of peptide based pro-drugs that us PepT1 and PepT2, mammalian homologues, to improve oral drug delivery. Here I tried to classify 46 POT family transporters on the basis of transmembrane α-helical spanners and to establish evolutionary relationship between POT family members and by sequence alignment technique looked into residues conserved in POT family members.