Nuclease activity and anti-proliferative effect on human cancerous cells of a newly synthesized and characterized mononuclear copper(ii) complex [CuII(L)(fu)2] [L = 2-(2-pyridyl)benzimidazole, fu = furoate]
| dc.contributor.author | Kaur, Gurpreet | |
| dc.contributor.author | Choudhury, A.R. | |
| dc.date.accessioned | 2020-12-14T05:28:07Z | |
| dc.date.available | 2020-12-14T05:28:07Z | |
| dc.date.issued | 2014 | |
| dc.description | Only IISERM authors are available in the record. | |
| dc.description.abstract | A mononuclear copper(ii) complex [CuII(L)(fu)2] (1) [L = 2-(2-pyridyl)benzimidazole, fu = furoate] has been synthesized and characterized by X-ray crystallography. Structural analysis reveals that 1 adopts a distorted square pyramidal geometry with CuN2O3 chromophore. Spectrophotometric and hydrodynamic investigations suggest that the complex binds with DNA in an intercalative mode with a binding constant of (3.19 ± 0.32) × 104 M-1. 1 induces oxidative cleavage of the supercoiled DNA to its nicked circular as well as linear forms. 1 is also proved to be an anti-cancer agent on human keratinocyte cells. | en_US |
| dc.identifier.citation | RSC Advances, 4(106), pp.61337-61342. | en_US |
| dc.identifier.other | https://doi.org/10.1039/C4RA09448D | |
| dc.identifier.uri | https://pubs.rsc.org/en/content/articlelanding/2014/RA/C4RA09448D#!divAbstract | |
| dc.identifier.uri | http://hdl.handle.net/123456789/3086 | |
| dc.language.iso | en | en_US |
| dc.publisher | Royal Society of Chemistry | en_US |
| dc.subject | Chromophores | en_US |
| dc.subject | Anti-proliferative effect | en_US |
| dc.subject | Mononuclear copper | en_US |
| dc.subject | Anti-cancer agents | en_US |
| dc.title | Nuclease activity and anti-proliferative effect on human cancerous cells of a newly synthesized and characterized mononuclear copper(ii) complex [CuII(L)(fu)2] [L = 2-(2-pyridyl)benzimidazole, fu = furoate] | en_US |
| dc.type | Article | en_US |