Detection of structurally different Aβ oligomers using lipid-laden aqueous liquid crystal interfaces
| dc.contributor.author | Najiya | |
| dc.date.accessioned | 2019-09-25T12:41:14Z | |
| dc.date.available | 2019-09-25T12:41:14Z | |
| dc.date.issued | 2019-09-25 | |
| dc.description.abstract | In this project, we attempt to use liquid crystals (LC) as a tool for differentiating two different types of soluble, structured Aβ oligomers- prefibrillar (A11 active oligomer) and fibrillar oligomers (OC active oligomer) based on their interaction with lipid monolayer at lipid-laden aqueous LC interface. Alzheimer's disease (AD) is mainly caused due to the neurotoxic assemblies of Aβ peptides. Using LC as a probe gives the benefit of an easy optical readout of the events occurring at the interface over time. This can thus serve as a basis for a possible amyloid-sensing mechanism and help in early detection of AD. | en_US |
| dc.description.sponsorship | IISERM | en_US |
| dc.guide | Pal, S.K. | |
| dc.identifier.uri | IISERM | en_US |
| dc.identifier.uri | http://hdl.handle.net/123456789/1136 | |
| dc.language.iso | en | en_US |
| dc.publisher | IISERM | en_US |
| dc.subject | Chemistry | en_US |
| dc.subject | liquid crystal | en_US |
| dc.subject | lipid monolayer | en_US |
| dc.subject | Grayscale intensity | en_US |
| dc.subject | Optical Microscopy | en_US |
| dc.title | Detection of structurally different Aβ oligomers using lipid-laden aqueous liquid crystal interfaces | en_US |
| dc.type | Thesis | en_US |