Cu‐Catalyzed Hydrophosphonylation of 2‐(2‐Enynyl)pyridines: Easy Access to Indolizine‐Containing Diarylmethylphosphonates

Abstract

An efficient protocol for the synthesis of indolizine‐containing unsymmetrical diarylmethylphosphonates through a Cu‐catalyzed 5‐endo‐dig ring‐closing reaction of 2‐(2‐enynyl)pyridines followed by remote hydrophosphonylation is described. A competent method for the synthesis of indolizine‐based diarylmethylphosphonates is described. This protocol involves a metal‐catalyzed 5‐endo‐dig‐cyclization of 2‐(2‐enynyl)pyridine derivatives followed by a remote addition of diarylphosphites to provide indolizine‐containing diarylmethylphosphonates in good yields.