Synthesis and crystal structures of pyridine-2-carboxaldehyde thiosemicarbazone, its mononuclear and cytotoxic Cu(II) and polynuclear Pb(II) complexes: Effect of size of metal ion on nucleation of the complexes

Abstract

Synthesis and X-ray structural characterization of pyridine-2- carboxaldehyde thiosemicarbazone (L), and its metal complexes, [Cu(L)(OH2)](ClO4)2 and [Pb(L)(ONO2)2]n are reported. X-ray diffraction reveals that the metal centres in the two complexes are distorted square planar and square pyramid geometries, respectively. Among the three compounds [Cu(L)(OH2)](ClO4)2 is found to be active against human keratinocyte cell line.