One-pot, solvent-free Pd(II)-catalyzed direct β-C-H arylation of carboxamides involving anhydrides as substrates via in situ installation of directing group
| dc.contributor.author | Dalal, A. | |
| dc.contributor.author | Singh, Prabhakar | |
| dc.contributor.author | Babu, S.A. | |
| dc.date.accessioned | 2020-11-25T07:03:31Z | |
| dc.date.available | 2020-11-25T07:03:31Z | |
| dc.date.issued | 2019 | |
| dc.description.abstract | A one-pot, multicomponent-type, solvent-free Pd(II)-catalyzed direct β-C-H activation/arylation of carboxamides involving anhydrides as substrates via in situ installation of directing group (DG) is reported. Typically, the DG-assisted β-C-H activation/arylation of carboxamides is a two-step process comprising the installation of DG and Pd(II)-catalyzed Csingle bondH arylation. We attempted a multicomponent-type reaction comprising an anhydride, a DG (e.g. 8-aminoquinoline), an aryl iodide in the presence of the Pd(II) catalyst and an appropriate additive. Different anhydrides, DGs, aryl iodides, catalysts and additives were screened to reveal the scope of this multicomponent-type Csingle bondH arylation reaction process and various β-C-H arylated carboxamides were obtained in satisfactory to good yields. | en_US |
| dc.identifier.citation | Tetrahedron, 75(9), pp.1246-1257. | en_US |
| dc.identifier.other | https://doi.org/10.1016/j.tet.2019.01.042 | |
| dc.identifier.uri | https://www.sciencedirect.com/science/article/pii/S004040201930081X | |
| dc.identifier.uri | http://hdl.handle.net/123456789/2189 | |
| dc.language.iso | en | en_US |
| dc.publisher | Elsevier | en_US |
| dc.subject | Multicomponent-type | en_US |
| dc.subject | Typically | en_US |
| dc.subject | Carboxamides | en_US |
| dc.title | One-pot, solvent-free Pd(II)-catalyzed direct β-C-H arylation of carboxamides involving anhydrides as substrates via in situ installation of directing group | en_US |
| dc.type | Article | en_US |