Palladium(II)‐Promoted Directing Group‐Enabled Regioselective C‐H Arylation of The C‐3 Position of 2‐ or 3‐(Aminoalkyl)‐Thiophene and Furfurylamine Derivatives
| dc.contributor.author | Rajkumar, V. | |
| dc.contributor.author | Naveen | |
| dc.contributor.author | Babu, S.A. | |
| dc.date.accessioned | 2020-12-02T10:45:09Z | |
| dc.date.available | 2020-12-02T10:45:09Z | |
| dc.date.issued | 2016 | |
| dc.description.abstract | The palladium(II)‐promoted, bidentate ligand‐assisted regioselective C−H activation/arylation of the C‐3 position of 2‐ or 3‐(aminoalkyl)‐thiophene and furfurylamine derivatives with various aryl‐/heteroaryl iodides was reported. Various aryl‐/heteroaryl iodides and bidentate ligands, such as, picolinamide, quinoline‐2‐carboxamide, pyrazine‐2‐carboxamide and oxalylamide were examined for accomplishing the regioselective palladium(II)‐promoted C−H arylation and C−C bond formation at the C‐3 position of the 2‐/3‐(aminoalkyl)‐thiophene and furfurylamine derivatives. The X‐ray structures of the regioisomers 8 c and 9 c confirmed the observed regiselectivity. This C−H activation/arylation method gave an access to several C3‐arylated 2/3‐(aminoalkyl)‐thiophene‐ and furfurylamine based biaryl scaffolds that are analogous to biologically active C3‐arylated 2/3‐(aminoalkyl)‐thiophenes and furfurylamines. | en_US |
| dc.identifier.citation | ChemistrySelect, 1(6), pp. 1207-1219 | en_US |
| dc.identifier.other | https://doi.org/10.1002/slct.201600296 | |
| dc.identifier.uri | https://chemistry-europe.onlinelibrary.wiley.com/doi/full/10.1002/slct.201600296 | |
| dc.identifier.uri | http://hdl.handle.net/123456789/2532 | |
| dc.language.iso | en | en_US |
| dc.publisher | Wiley-Blackwell | en_US |
| dc.subject | Biaryls | en_US |
| dc.subject | C−H activation | en_US |
| dc.subject | Palladium | en_US |
| dc.subject | Regioselectivity | en_US |
| dc.subject | Synthetic methods | en_US |
| dc.title | Palladium(II)‐Promoted Directing Group‐Enabled Regioselective C‐H Arylation of The C‐3 Position of 2‐ or 3‐(Aminoalkyl)‐Thiophene and Furfurylamine Derivatives | en_US |
| dc.type | Article | en_US |