A Computational Study on Cardiolipin - Cytochrome C Interactions on a 5CB Liquid Crystal Droplet Surface

Abstract

Protein-lipid interactions are essential for maintaining the structural integrity of cel lular membranes. Cardiolipin-Cytochrome C interactions play a vital role in the coherence of the mitochondrial membrane and apoptosis. Delineating the interaction has been a research interest for a long time, but remains elusive. This study focuses on cardiolipin-Cytochrome C interactions on a liquid crystalline droplet surface using molecular dynamics (MD) simulations, which have been used as a major tool for bio physical and biochemical studies. Significant insights into the interactions were gained through this work on the nature of interactions as well as the interacting residues