Synthesis of Biologically Relevant Molecules Via Organometallic Methodologies

Abstract

Efforts toward developing various examples of agrochemically active or biologically relevant molecules via organometallic methodologies where a variety of cinnamamide based molecules have been synthesized via the Mizoroki–Heck Cross- Coupling Reaction. Alongside, the synthesis of β-nitrile equipped N-arylated amino acid derivatives via nucleophilic addition of bromoacetonitrile or 2- bromopropanenitrile to α-imino esters followed by hydrolysis and dipeptides composed of nitrile attached unnatural α-amino acid were also synthesized.