Enamine/enolate-mediated organocatalytic azide- Carbonyl [3+2] cycloaddition reactions for the synthesis of densely functionalized 1,2,3-triazoles

Abstract

Recent advances in the metal‐free enamine/enolate‐mediated azide–carbonyl [3+2] cycloaddition reaction are discussed. These approaches require neither a metal catalyst nor alkyne substrates. Owing to the ready availability of carbonyl compounds, these methods thus offer excellent alternatives for the synthesis of 1,4‐/1,5‐disubstituted and 1,4,5‐trisubstituted 1,2,3‐triazoles.