Mechanics of Cell Migration Using Motor-Clutch Model and Optimality in Cell Migration

Abstract

As we know that cell migration is a very important process in life, from the development of embryos continuing until death. The extracellular environment impacts the cell to a great extent in migration. Many cells exhibit a sti⇥ness optimum at which the migration is maximum. This optimum sti⇥ness varies over vast ranges depending on the cell. In this thesis, I give an account of a motor-clutch model of cell traction which displays a maximum in traction force with respect to substrate sti⇥ness. I look at this optimality with varying parameter values. Finally I incorporate motor attachment/detachment to see the e⇥ect of this variation on the cell migration model.