Mammalian proapoptotic factor ChaC1 and its homologues function as γ-glutamyl cyclotransferases acting specifically on glutathione
| dc.contributor.author | Kaur, Amandeep | |
| dc.contributor.author | Bachhawat, A.K. | |
| dc.date.accessioned | 2021-01-04T04:31:46Z | |
| dc.date.available | 2021-01-04T04:31:46Z | |
| dc.date.issued | 2012 | |
| dc.description | Only IISERM authors are available in the record. | |
| dc.description.abstract | ChaC1 is a mammalian proapoptic protein of unknown function induced during endoplasmic reticulum stress. We show using in vivo studies and novel in vitro assays that the ChaC family of proteins function as γ-glutamyl cyclotransferases acting specifically to degrade glutathione but not other γ-glutamyl peptides. The overexpression of these proteins (but not the catalytically dead E>Q mutants) led to glutathione depletion and enhanced apoptosis in yeast. The ChaC family is conversed across all phyla and represents a new pathway for glutathione degradation in living cells, and the first cytosolic pathway for glutathione degradation in mammalian cells | en_US |
| dc.identifier.citation | EMBO Reports, 13(12) PP. 1095-1101. | en_US |
| dc.identifier.other | 10.1038/embor.2012.156 | |
| dc.identifier.uri | https://www.embopress.org/doi/full/10.1038/embor.2012.156 | |
| dc.identifier.uri | http://hdl.handle.net/123456789/3494 | |
| dc.language.iso | en_US | en_US |
| dc.publisher | European Molecular Biology Organization. | en_US |
| dc.subject | γ-glutamyl cyclotransferases | en_US |
| dc.subject | 5-oxoproline | en_US |
| dc.subject | apoptosis | en_US |
| dc.subject | ChaC1 | en_US |
| dc.title | Mammalian proapoptotic factor ChaC1 and its homologues function as γ-glutamyl cyclotransferases acting specifically on glutathione | en_US |
| dc.type | Article | en_US |