Pentacarbomethoxycyclopentadiene Mediated one pot Synthesis of Indanone Derivatives from para-quinone Methides

Abstract

Pentacarbomethoxycyclopentadiene (PCCP) has been utilized as a non-covalent Br Ø nsted acid for the intramolecular cyclization of alkenylated para-Quinone Methides to form indanone based product. This transformation is tolerant to a variety of functional groups and occurs at mild conditions. This methodology provides an easy and straightforward access to a set of indanones in moderate to good yield which are present as a core in multiple natural products like isopaucifloral (F), quadrangularin A etc.