Pd-Catalysed [3 + 2]-cycloaddition towards the generation of bioactive bis-heterocycles/identification of COX-2 inhibitors via in silico analysis
| dc.contributor.author | Ansari, Arshad J. | |
| dc.date.accessioned | 2023-08-21T14:14:54Z | |
| dc.date.available | 2023-08-21T14:14:54Z | |
| dc.date.issued | 2022 | |
| dc.description | Only IISER Mohali authors are available in the record. | en_US |
| dc.description.abstract | In the current research, we envisaged the synthesis of bis-heterocycles containing the dihydroisoxazole ring by [3 + 2] cycloaddition of VECs (vinyl ethylene carbonates) and nitrile oxides, assisted by a Pd catalyst. Herein we explored hydroximoyl chlorides as versatile precursors for the in situ generation of nitrile oxides that were exploited to achieve the cycloaddition reaction on a vinyl group of VECs to generate bis-heterocycles. In silico-based studies of bis-heterocycles on the cyclooxygenase (COX) enzyme displayed selective COX-2 inhibition. | en_US |
| dc.identifier.citation | Organic and Biomolecular Chemistry, 20(23), 4746-4752. | en_US |
| dc.identifier.uri | https://doi.org/10.1039/d2ob00467d | |
| dc.identifier.uri | http://hdl.handle.net/123456789/4985 | |
| dc.language.iso | en_US | en_US |
| dc.publisher | Royal Society of Chemistry | en_US |
| dc.subject | Pd-Catalysed [3 + 2]-cycloaddition | en_US |
| dc.subject | identification of COX-2 | en_US |
| dc.subject | silico analysis | en_US |
| dc.title | Pd-Catalysed [3 + 2]-cycloaddition towards the generation of bioactive bis-heterocycles/identification of COX-2 inhibitors via in silico analysis | en_US |
| dc.type | Article | en_US |