Tandem One-Pot Approach to Access 1,2,3-Triazole-fused Isoindolines through Cu-Catalyzed 1,6-Conjugate Addition of Me3SiN3 to p-Quinone Methides followed by Intramolecular Click Cycloaddition
| dc.contributor.author | Jadhav, A.S. | |
| dc.contributor.author | Pankhade, Y.A. | |
| dc.contributor.author | Anand, R.V. | |
| dc.date.accessioned | 2020-11-19T10:21:02Z | |
| dc.date.available | 2020-11-19T10:21:02Z | |
| dc.date.issued | 2018 | |
| dc.description.abstract | A Cu-catalyzed one-pot approach has been developed for the synthesis of 1,2,3-triazole-fused tricyclic heterocycles. This tandem approach actually involves the 1,6-conjugate addition of Me3SiN3 to o-alkynylated p-quinone methides followed by an intramolecular [3+2]-cycloaddition reaction. This protocol allowed us to access a wide range of 1,2,3-trazole-fused isoindoline derivatives in moderate to good yields. | en_US |
| dc.identifier.citation | Journal of Organic Chemistry, 83(15), pp. 8596-8606 | en_US |
| dc.identifier.other | https://doi.org/10.1021/acs.joc.8b00573 | |
| dc.identifier.uri | https://pubs.acs.org/doi/10.1021/acs.joc.8b00573 | |
| dc.identifier.uri | http://hdl.handle.net/123456789/1915 | |
| dc.language.iso | en | en_US |
| dc.publisher | American Chemical Society | en_US |
| dc.subject | Cycloaddition Reactions | en_US |
| dc.subject | Arylation | en_US |
| dc.subject | Benzyne | en_US |
| dc.subject | Cycloaddition | en_US |
| dc.subject | Catalysis | en_US |
| dc.title | Tandem One-Pot Approach to Access 1,2,3-Triazole-fused Isoindolines through Cu-Catalyzed 1,6-Conjugate Addition of Me3SiN3 to p-Quinone Methides followed by Intramolecular Click Cycloaddition | en_US |
| dc.type | Article | en_US |