Zinc - Mediated Nucleophilic Addition of Bromoacetonitrile to Isatin Ketimines

Abstract

Formation of various oxindole derivatives via nucleophilic addition of bromoacetonitrile to different kinds of isatin ketimines is reported. Zinc-mediated nucleophilic addition of bromoacetonitrile to simple isatin ketimines and chiral isatin ketimines gave various oxindole derivatives with good yield and stereoselectivity.