Deciphering the Role of Developing Brain Homeobox Genes During Zebrafish Retina Regeneration

Abstract

In contrast to mammals, Zebra fish shows complete retinal regeneration in response to injury. Muller Glia cells play a very critical role in the process of Retina regeneration in Zebra fish. Process of retinal regeneration gets completed in three stages: Dedifferentiation, Proliferation, and Re differentiation. Here I report that, Developing Brain Homeobox Genes are robustly expressed in Ganglion cell layer, Horizontal cells in INL and Muller Glia of regenerating retina also, playing a role in the process of regeneration. I also report that, dbx expression might be regulated by Wnt-β catenin signalling pathway.