Pd(OAc)2-Catalyzed, AgOAc-Promoted Z Selective Directed β-Arylation of Acrylamide Systems and Stereoselective Construction of Z-Cinnamamide Scaffolds
| dc.contributor.author | Parella, R. | |
| dc.contributor.author | Babu, S.A. | |
| dc.date.accessioned | 2020-12-07T07:02:06Z | |
| dc.date.available | 2020-12-07T07:02:06Z | |
| dc.date.issued | 2015 | |
| dc.description.abstract | A Pd(OAc)2-catalyzed, AgOAc-promoted and bidentate ligand-directed Z selective C–H activation, followed by the β-arylation of the C(sp2)–H bond of N-(quinolin-8-yl)acrylamide systems with aryl- and heteroaryl iodides, and a contemporary method for the construction of various Z-cinnamamides and β,β-diarylated acrylamides are reported. A plausible reaction mechanism comprising the bidentate ligand-aided, chelation-based C–H functionalization was proposed for the observed Z selective β-arylation of N-(quinolin-8-yl)acrylamide systems. | en_US |
| dc.identifier.citation | Journal of Organic Chemistry, 80(24) | en_US |
| dc.identifier.other | 10.1021/acs.joc.5b02264 | |
| dc.identifier.uri | https://pubs.acs.org/doi/abs/10.1021/acs.joc.5b02264 | |
| dc.identifier.uri | http://hdl.handle.net/123456789/2732 | |
| dc.language.iso | en_US | en_US |
| dc.publisher | American Chemical Society | en_US |
| dc.subject | Amides | en_US |
| dc.subject | Stereochemistry | en_US |
| dc.subject | Molecular structure | en_US |
| dc.subject | Arylation | en_US |
| dc.title | Pd(OAc)2-Catalyzed, AgOAc-Promoted Z Selective Directed β-Arylation of Acrylamide Systems and Stereoselective Construction of Z-Cinnamamide Scaffolds | en_US |
| dc.type | Article | en_US |