Comprehensive study towards the desulfonylation/desulfinylation of cis-3-functionalized 3-phenylsulfonyl/sulfinyl-β-lactams to access novel cis-3-monosubstituted-β-lactams
| dc.contributor.author | Khullar, S. | |
| dc.contributor.author | Mandal, S.K. | |
| dc.date.accessioned | 2020-11-19T09:22:28Z | |
| dc.date.available | 2020-11-19T09:22:28Z | |
| dc.date.issued | 2018 | |
| dc.description | Only IISERM authors are available in the record. | |
| dc.description.abstract | An inclusive study towards the stereospecific synthesis of novel cis-3-monosubstituted-β-lactams from cis-3-functionalized 3-phenylsulfonyl/sulfinyl-β-lactams is described. 3-Sulfinyl-β-lactams 5/5ʹ successfully furnished stereospecific cis-3-monosubstituted-β-lactams 6, however 3-sulfonyl-β-lactams 2 failed to give the desulfurized product 6ʹ. The final stereochemical and structural conformations of novel β-lactams were established by single crystal X-ray crystallographic study (5c). The cis configuration of the β-lactams 5/5ʹ and 6 was assigned in relevance to E and C4-H and C3-H and C4-H respectively. | en_US |
| dc.identifier.citation | Tetrahedron, 74(33), pp. 4400-4408 | en_US |
| dc.identifier.other | https://doi.org/10.1016/j.tet.2018.07.008 | |
| dc.identifier.uri | https://www.sciencedirect.com/science/article/pii/S0040402018307993 | |
| dc.identifier.uri | http://hdl.handle.net/123456789/1903 | |
| dc.language.iso | en | en_US |
| dc.publisher | Elsevier Ltd | en_US |
| dc.subject | Trans-3-Phenylsulfinyl-β-lactams | en_US |
| dc.subject | C-3 functionalization | en_US |
| dc.subject | Michael addition | en_US |
| dc.subject | Desulfonylation | en_US |
| dc.title | Comprehensive study towards the desulfonylation/desulfinylation of cis-3-functionalized 3-phenylsulfonyl/sulfinyl-β-lactams to access novel cis-3-monosubstituted-β-lactams | en_US |
| dc.type | Article | en_US |