Facile synthesis of novel monocyclic trans- and cis-3-oxy/thio/seleno-4-pyrazolyl-β-lactams
| dc.contributor.author | Mandal, S. | |
| dc.contributor.author | Khullar, S. | |
| dc.date.accessioned | 2020-12-08T08:57:40Z | |
| dc.date.available | 2020-12-08T08:57:40Z | |
| dc.date.issued | 2015 | |
| dc.description | Only IISERM authors are available in the record. | |
| dc.description.abstract | A facile synthesis of novel monocyclic trans- and cis-3-oxy/thio/seleno-4-pyrazolyl-β-lactams (5, 6) is described. The reaction of 2-methoxy/phenoxy/benzyl/phenylthio/seleno ethanoic acids or acetoxyacetyl chloride 4 with pyrazolyl substituted Schiff's bases 3a-d using POCl3 and Et3N in refluxing toluene furnished β-lactams (5, 6). These synthesized β-lactams have been characterized by spectroscopic techniques viz. NMR (1H, 13C and 77Se), FT-IR, mass spectrometry (EI-MS and HRMS) and elemental analysis. Single crystal X-ray crystallographic study of trans-1-(4′-methoxyphenyl)-3-methoxy-4-(5′-chloro-3′-methyl-1′-phenyl-1H-pyrazol-4′-yl)azetidin-2-one 5p has confirmed the molecular structure and the stereochemical outcome. The cis or trans configuration of β-lactams (5, 6) was assigned with respect to position of C3-H and C4-H. © 2015 ARKAT-USA, Inc. | en_US |
| dc.identifier.citation | Arkivoc, 2015(7) | en_US |
| dc.identifier.other | 10.3998/ark.5550190.p009.172 | |
| dc.identifier.uri | https://quod.lib.umich.edu/a/ark/5550190.p009.172?view=pdf | |
| dc.identifier.uri | http://hdl.handle.net/123456789/2819 | |
| dc.language.iso | en_US | en_US |
| dc.publisher | Arkat | en_US |
| dc.subject | Pyrazole derivatives | en_US |
| dc.subject | Trans- and cis-3-oxy/thio/seleno-4-pyrazolyl-β-lactams | en_US |
| dc.subject | X-ray crystal structure | en_US |
| dc.subject | β-Lactams | en_US |
| dc.title | Facile synthesis of novel monocyclic trans- and cis-3-oxy/thio/seleno-4-pyrazolyl-β-lactams | en_US |
| dc.type | Article | en_US |