Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/1351
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dc.contributor.authorGopalakrishnan, B.-
dc.date.accessioned2019-11-25T16:34:52Z-
dc.date.available2019-11-25T16:34:52Z-
dc.date.issued2019-11-25-
dc.identifier.uriIISERMen_US
dc.identifier.urihttp://hdl.handle.net/123456789/1351-
dc.description.abstractThe transition metal-catalyzed C(sp 3 )-H and C(sp 2 )-H functionalization is emerging as one of the important synthetic transformations for the construction of C–C and C–X bonds (X = C, N, O, P, etc.). This thesis work aimed to synthesize functionalized aliphatic chains containing stereogenic centers through the Pd-catalyzed directing group-aided diastereoselective C(sp 3 )-H functionalization/arylation strategy. Accordingly, the bidentate directing group 8-aminoquinoline- aided Pd(II)-catalyzed diastereoselective β-arylation of the prochiral secondary sp 3 C-H bonds of 2-phenylbutanamides and related aliphatic carboxamides was reported. Next, the diastereoselective sp 3 C−H arylation followed by ring opening of cyclopropanecarboxamides was reported. Further, bis-arylation of methyl sp 3 C-H bonds of racemic and optically pure 2-arylpropionamides and desymmetrization of symmetrical dicarboxylic acid systems via arylation of methylene sp 3 C-H bonds were reported.en_US
dc.language.isoen_USen_US
dc.publisherIISERMen_US
dc.subjectMetal-catalyzeden_US
dc.subjectDicarboxylic aciden_US
dc.subjectMethyleneen_US
dc.subjectBondsen_US
dc.titleStudies on Stereoselective Synthesis of Functionalized Aliphatic Chains Containing Stereogenic Centers through the Pd(II)- Catalyzed C-H Activationen_US
dc.typeThesisen_US
dc.guideBabu, S.A.-
Appears in Collections:PhD-2012

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