Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/136
Title: Unactivated Norbornenes in [3+2] Cycloadditions: Remarkably Stereocon- trolled Entry into Norbornane-Fused-Spirooxindolopyrrolidines, Spiro-1,3- in- dandionolylpyrrolidines and Spirooxindolopyrrolizidines
Authors: Rajkumar, V.
Aslam, N.A.
Reddy, C.
Babu, S.A.
Keywords: 1,3-dipolar cycloaddition
oxindoles
spiro compounds
Issue Date: 2011
Publisher: Theime
Citation: Synlett, 23, 549-556
Abstract: 1,3-dipolar cycloaddition reactions of azomethine ylides with unactivated norbornene dipolarophiles and a highly diastereoselective synthesis of the novel norbornane-fused spirooxindolopyrrolidines, spiroacenaphthylenolylpyrrolidines, spiro-1,3-indandionolylpyrrolidines, and spirooxindolopyrrolizidines having an array of stereocenters are reported. The stereoselective synthesis of spirooxindolopyrrolizidines with eight stereocenters was demonstrated. Single-crystal X-ray structural analyses were performed to unambiguously establish the structure and stereochemistry of the key products.
URI: https://www.thieme-connect.de/ejournals/pdf/10.1055/s-0031-1290342.pdf
10.1055/s-0031-1290342; Art ID: D52011ST
Appears in Collections:Research Articles

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