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http://hdl.handle.net/123456789/1789
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DC Field | Value | Language |
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dc.contributor.author | Dahiya, Y. | - |
dc.contributor.author | Rose, Saloni | - |
dc.contributor.author | Thapliyal, Shruti | - |
dc.contributor.author | Bhardwaj, Shivam | - |
dc.contributor.author | Prasad, Maruthi | - |
dc.contributor.author | Babu, Kavita | - |
dc.date.accessioned | 2020-11-18T09:08:47Z | - |
dc.date.available | 2020-11-18T09:08:47Z | - |
dc.date.issued | 2019 | - |
dc.identifier.citation | The Journal of neuroscience : the official journal of the Society for Neuroscience,39(40),pp.7934-7946. | en_US |
dc.identifier.other | https://doi.org/10.1523/JNEUROSCI.0006-19.2019 | - |
dc.identifier.uri | https://www.jneurosci.org/content/early/2019/08/13/JNEUROSCI.0006-19.2019/tab-e-letters?versioned=true | - |
dc.identifier.uri | http://hdl.handle.net/123456789/1789 | - |
dc.description.abstract | Memory formation is crucial for the survival of animals. Here, we study the effect of different crh-1 (C. elegans homolog of mammalian CREB1) isoforms on the ability of C. elegans to form long-term memory (LTM). Null mutants in creb1/crh-1 are defective in LTM formation across phyla. We show that a specific isoform of CREB1/CRH-1, CRH-1e, is primarily responsible for memory related functions of the transcription factor in C. elegans. Silencing of CRH-1e expressing neurons during training for LTM formation abolishes the long-term memory of the animal. Further, CRH-1e expression in RIM neurons is sufficient to rescue long-term memory defects of creb1/crh-1 null mutants. We go on to show that apart from being LTM defective, creb1/crh-1 null animals show defects in innate chemotaxis behavior. We further characterize the amino acids K247 and K266 as responsible for the LTM related functions of CREB1/CRH-1 while being dispensable for its innate chemotaxis behavior. These findings provide insight into the spatial and temporal workings of a crucial transcription factor that can be further exploited to find CREB1 targets involved in the process of memory formation. | en_US |
dc.language.iso | en | en_US |
dc.publisher | The Journal of neuroscience : the official journal of the Society for Neuroscience | en_US |
dc.subject | Mammalian | en_US |
dc.subject | CREB1/CRH-1 | en_US |
dc.subject | CRH-1e expression | en_US |
dc.title | Differential Regulation of Innate and Learned Behavior by Creb1/Crh-1 in Caenorhabditis elegans | en_US |
dc.type | Article | en_US |
Appears in Collections: | Research Articles |
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