Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/1903
Title: Comprehensive study towards the desulfonylation/desulfinylation of cis-3-functionalized 3-phenylsulfonyl/sulfinyl-β-lactams to access novel cis-3-monosubstituted-β-lactams
Authors: Khullar, S.
Mandal, S.K.
Keywords: Trans-3-Phenylsulfinyl-β-lactams
C-3 functionalization
Michael addition
Desulfonylation
Issue Date: 2018
Publisher: Elsevier Ltd
Citation: Tetrahedron, 74(33), pp. 4400-4408
Abstract: An inclusive study towards the stereospecific synthesis of novel cis-3-monosubstituted-β-lactams from cis-3-functionalized 3-phenylsulfonyl/sulfinyl-β-lactams is described. 3-Sulfinyl-β-lactams 5/5ʹ successfully furnished stereospecific cis-3-monosubstituted-β-lactams 6, however 3-sulfonyl-β-lactams 2 failed to give the desulfurized product 6ʹ. The final stereochemical and structural conformations of novel β-lactams were established by single crystal X-ray crystallographic study (5c). The cis configuration of the β-lactams 5/5ʹ and 6 was assigned in relevance to E and C4-H and C3-H and C4-H respectively.
Description: Only IISERM authors are available in the record.
URI: https://www.sciencedirect.com/science/article/pii/S0040402018307993
http://hdl.handle.net/123456789/1903
Appears in Collections:Research Articles

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