Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/2007
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dc.contributor.authorSingh, Prabhakar-
dc.contributor.authorDalal, A.-
dc.contributor.authorBabu, S.A.-
dc.date.accessioned2020-11-21T05:10:12Z-
dc.date.available2020-11-21T05:10:12Z-
dc.date.issued2019-
dc.identifier.citationAsian Journal of Organic Chemistry, 8(6), pp. 877-886.en_US
dc.identifier.otherhttps://doi.org/10.1002/ajoc.201900132-
dc.identifier.urihttps://onlinelibrary.wiley.com/doi/full/10.1002/ajoc.201900132-
dc.identifier.urihttp://hdl.handle.net/123456789/2007-
dc.description.abstractA dual objective‐based study comprising exploration of 5‐methylisoxazole‐3‐carboxamide (MICA) as a directing group (DG) for the Pd(II)‐catalyzed sp3/sp2 γ‐ and δ‐C−H activation/functionalization of aryl amines and assembling of various MICA motifs are reported. The Pd(II)‐catalyzed MICA‐aided γ‐C(sp3)‐H arylation/acetoxylation of ortho‐toluidines gave various 2‐aminodiphenylmethanes and 2‐aminobenzyl acetates, respectively. The Pd(II)‐catalyzed MICA‐aided γ‐C(sp2)‐H arylation/acetoxylation of benzylamines gave the corresponding arylated/acetoxylated products. Furthermore, the Pd(II)‐catalyzed MICA‐aided δ‐C(sp2)‐H amidation/alkenylation of phenethylamines were also explored. Representative control reactions were done to assess the relative effectiveness of MICA for the γ‐C(sp3)‐H arylation and MICA is a removable DG. Apart from the usage of MICA as a DG for the sp2/sp3 C−H functionalization of aryl amines, indirectly this process has led to the construction of a library of MICA motifs. This is an added advantage to note as the MICA‐based motifs are valuable small molecules in medicinal chemistry.en_US
dc.language.isoenen_US
dc.publisherWiley Online Libraryen_US
dc.subjectC−H activationen_US
dc.subjectDirecting groupen_US
dc.subjectIsoxazole-3-carboxamidesen_US
dc.subjectPalladiumen_US
dc.titlePalladium(II)‐Catalyzed Sp3/Sp2γ‐ and δ‐C‐H Functionalization of Aryl Amines using 5‐Methylisoxazole‐3‐Carboxamide as Directing Groupen_US
dc.typeArticleen_US
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