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DC Field | Value | Language |
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dc.contributor.author | Nandi, Rajib | - |
dc.date.accessioned | 2020-11-25T04:01:16Z | - |
dc.date.available | 2020-11-25T04:01:16Z | - |
dc.date.issued | 2018 | - |
dc.identifier.citation | Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, 190, pp. 177-180 | en_US |
dc.identifier.other | https://doi.org/10.1016/j.saa.2017.09.016 | - |
dc.identifier.uri | https://www.sciencedirect.com/science/article/pii/S1386142517307345 | - |
dc.identifier.uri | http://hdl.handle.net/123456789/2147 | - |
dc.description | Only IISERM authors are available in the record. | - |
dc.description.abstract | The α and γ polymorphs of drug pyrazinamide have been detected with the help of temperature dependent Raman spectroscopic technique. Pyrazinamide is a very useful drug used for the treatment of tuberculosis (TB) and plays a significant role in destroying the dormant tubercle bacilli which are not destroyed by other common TB drugs. Temperature dependent Raman spectra suggest polymorphic phase change from α → γ form of pyrazinamide between 145 and 146 °C. In situ Raman spectra of pyrazinamide between 145 and 146 °C show the conversion of α → γ form by the shift in Cdouble bondO stretching vibration accompanied by several other changes. The phase change is characterized by the breaking of two linear Nsingle bondH ⋯ O type hydrogen bonds associated with Cdouble bondO stretching vibration in α dimer and formation of one linear Nsingle bondH ⋯ N type hydrogen bond along with a weak intramolecular Csingle bondH ⋯ O type hydrogen bond in the γ dimer. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Elsevier B.V. | en_US |
dc.subject | Pyrazinamide | en_US |
dc.subject | Tuberculosis | en_US |
dc.subject | Hydrogen bonding | en_US |
dc.subject | Raman spectroscopy | en_US |
dc.subject | DFT | en_US |
dc.title | Temperature dependent polymorphism of pyrazinamide: An in situ Raman and DFT study | en_US |
dc.type | Article | en_US |
Appears in Collections: | Research Articles |
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