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http://hdl.handle.net/123456789/2570| Title: | N-Heterocyclic Carbene Catalyzed 1,6-Conjugate Addition of Me3Si-CN to para-Quinone Methides and Fuchsones: Access to α-Arylated Nitriles |
| Authors: | Goswami, P. Singh, Gurdeep Anand, R.V. |
| Keywords: | Chemical reactions, Nitrogen compounds |
| Issue Date: | 2017 |
| Publisher: | ACS Publications |
| Citation: | Organic Letters, 19(8) |
| Abstract: | An organocatalytic approach toward α-arylated nitriles using N-heterocyclic carbene (NHC) as a catalyst is described. This protocol comprises an NHC catalyzed activation of Me3Si-CN followed by 1,6-conjugate addition of cyanide to para-quinone methides (p-QMs) and fuchsones leading to α-diaryl- and α-triaryl nitriles in good to excellent yields. |
| URI: | https://pubs.acs.org/doi/abs/10.1021/acs.orglett.7b00508 http://hdl.handle.net/123456789/2570 |
| Appears in Collections: | Research Articles |
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| Need to add pdf.odt | 8.63 kB | OpenDocument Text | View/Open |
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