
Please use this identifier to cite or link to this item:
http://hdl.handle.net/123456789/2732
Title: | Pd(OAc)2-Catalyzed, AgOAc-Promoted Z Selective Directed β-Arylation of Acrylamide Systems and Stereoselective Construction of Z-Cinnamamide Scaffolds |
Authors: | Parella, R. Babu, S.A. |
Keywords: | Amides Stereochemistry Molecular structure Arylation |
Issue Date: | 2015 |
Publisher: | American Chemical Society |
Citation: | Journal of Organic Chemistry, 80(24) |
Abstract: | A Pd(OAc)2-catalyzed, AgOAc-promoted and bidentate ligand-directed Z selective C–H activation, followed by the β-arylation of the C(sp2)–H bond of N-(quinolin-8-yl)acrylamide systems with aryl- and heteroaryl iodides, and a contemporary method for the construction of various Z-cinnamamides and β,β-diarylated acrylamides are reported. A plausible reaction mechanism comprising the bidentate ligand-aided, chelation-based C–H functionalization was proposed for the observed Z selective β-arylation of N-(quinolin-8-yl)acrylamide systems. |
URI: | https://pubs.acs.org/doi/abs/10.1021/acs.joc.5b02264 http://hdl.handle.net/123456789/2732 |
Appears in Collections: | Research Articles |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
Need to add pdf.odt | 8.63 kB | OpenDocument Text | View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.