Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/3456
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dc.contributor.authorBhardwaj, Ashwani-
dc.contributor.authorPandey, P.-
dc.contributor.authorBabu, Kavita-
dc.date.accessioned2020-12-30T10:31:15Z-
dc.date.available2020-12-30T10:31:15Z-
dc.date.issued2020-
dc.identifier.citationGenetics 214(1), pp. 135-145en_US
dc.identifier.otherhttps://doi.org/10.1534/genetics.119.302872-
dc.identifier.urihttps://www.genetics.org/content/214/1/135-
dc.identifier.urihttp://hdl.handle.net/123456789/3456-
dc.description.abstractCell surface immunoglobulin superfamily (IgSF) proteins play important roles in the development and function of the nervous system . Here we define the role of a Caenorhabditis elegans IgSF protein, RIG-3, in the function of the AVA command interneuron. This study reveals that RIG-3 regulates the abundance of the glutamate receptor subunit, GLR-1, in the AVA command interneuron and also regulates reversal behavior in C. elegans. The mutant strain lacking rig-3 (rig-3 (ok2156)) shows increased reversal frequency during local search behaviors. Genetic and behavioral experiments suggest that RIG-3 functions through GLR-1 to regulate reversal behavior. We also show that the increased reversal frequency seen in rig-3 mutants is dependent on the increase in GLR-1 abundance at synaptic inputs to AVA, suggesting that RIG-3 alters the synaptic strength of incoming synapses through GLR-1. Consistent with the imaging experiments, altered synaptic strength was also reflected in increased calcium transients in rig-3 mutants when compared to wild-type control animals. Our results further suggest that animals lacking rig-3 show increased AVA activity, allowing the release of FLP-18 neuropeptide from AVA, which is an activity-dependent signaling molecule. Finally, we show that FLP-18 functions through the neuropeptide receptor, NPR-5, to modulate reversal behavior in C. elegans.en_US
dc.language.isoenen_US
dc.publisherGenetics Society of Americaen_US
dc.subjectImmunoglobulinen_US
dc.subjectProteinsen_US
dc.subjectCaenorhabditis elegansen_US
dc.titleControl of Locomotory Behavior of Caenorhabditis elegans by the Immunoglobulin Superfamily Protein RIG-3en_US
dc.typeArticleen_US
Appears in Collections:Research Articles

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