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http://hdl.handle.net/123456789/3909
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DC Field | Value | Language |
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dc.contributor.author | Nivedha, B. | - |
dc.date.accessioned | 2021-09-30T09:45:34Z | - |
dc.date.available | 2021-09-30T09:45:34Z | - |
dc.date.issued | 2021-06-28 | - |
dc.identifier.uri | http://hdl.handle.net/123456789/3909 | - |
dc.description.abstract | Pre-mRNA splicing by the spliceosome is one of the steps where regulation of gene expression occurs. Various ubiquitin-like proteins (UBLs) have been shown to regulate pre-mRNA splicing. The UBL Hub1 is known to play a role in alternative splicing in Saccharomyces cerevisiae through its well-known surfaces. This study shows that the recently identified novel surface of Hub1 in Schizosaccharomyces pombe plays a significant role in cell growth and splicing. The various approaches of bioinformatic analysis, genetics and splicing assays suggest a possible link between Hub1 and transcription. This study also shows that Hub1 selectively modifies the spliceosome and that it might play a role in the transition of the spliceosome. Therefore, this study addresses the mechanism and function of Hub1 in Schizosaccharomyces pombe. | en_US |
dc.language.iso | en | en_US |
dc.publisher | IISERM | en_US |
dc.subject | UBL Hub1 | en_US |
dc.subject | mRNA | en_US |
dc.subject | Pre-mRNA | en_US |
dc.title | Role of the unconventional UBL Hub1 in pre-mRNA splicing | en_US |
dc.type | Thesis | en_US |
dc.guide | Mishra, Shravan Kumar | - |
Appears in Collections: | MS Dissertation by MP-2018 |
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It is under embargo period.odt | 9.47 kB | OpenDocument Text | View/Open |
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