Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/4050
Title: Unusual Reactions Mediated by the Corey-Chaykovsky Reagent to Synthesize Cyclopropa-Fused Dibenzocycloheptanoids
Authors: Chattopadhyay, Anwita
Keywords: Unusual Reactions
Corey-Chaykovsky
Fused Dibenzocycloheptanoids
Issue Date: Apr-2022
Publisher: IISER Mohali
Abstract: Utilizing the unique characteristics of the sulfoxonium ylides to undergo bi-functionalization reactions, our group has developed several unusual and proficient cyclopropanation strategies to access several highly functionalized and synthetically privileged motifs in single step from easy-to-prepare starting compounds. Subsequently, we planned to extend the scope of these methodologies. Hence, we have investigated the reactivity of sulfoxonium ylides with biaryl enone-aldehyde substrates, as this chemistry with sulfoxonium ylides is yet unexplored with biaryl scaffolds. It has been found that reaction of dioxosulfoxonium methylide (DOSM) with designed biaryl substrates deliver a series of cyclopropa-fused dibenzocycloheptanoid scaffolds in excellent yields. Dibenzocycloheptanoids represent the core of several bioactive natural products.
URI: http://hdl.handle.net/123456789/4050
Appears in Collections:MS-17

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