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DC Field | Value | Language |
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dc.contributor.author | Tomar, Radha | - |
dc.contributor.author | Kumar, Amit | - |
dc.contributor.author | Dalal, Arup | - |
dc.contributor.author | Bhattacharya, Debabrata | - |
dc.contributor.author | Singh, Prabhakar | - |
dc.contributor.author | Babu, Srinivasarao Arulananda | - |
dc.date.accessioned | 2023-08-10T11:17:59Z | - |
dc.date.available | 2023-08-10T11:17:59Z | - |
dc.date.issued | 2022 | - |
dc.identifier.citation | Asian Journal of Organic Chemistry, 11(9), 2200311 | en_US |
dc.identifier.uri | https://doi.org/10.1002/ajoc.202200311 | - |
dc.identifier.uri | http://hdl.handle.net/123456789/4471 | - |
dc.description | Only IISERM authors are available in the record | en_US |
dc.description.abstract | We have shown our efforts toward expanding the utility of the relatively inexpensive pyridine-N-oxide directing group in the Pd(II)-catalyzed site-selective γ-C(sp2)−H, γ-C(sp3)−H and δ-C(sp2)−H functionalization. The functionalization β−C−H bonds using bidentate directing group (DG) pyridine-N-oxide which operates through the N,O-coordination mode has been well documented in the literature. However, there exist rare reports dealing with the functionalization of remote sp2/sp3 γ- and δ-C−H bonds of carboxamides assisted by the bidentate directing groups operating via the N,O-coordination. In this paper, the scope of pyridine-N-oxide DG was examined for accomplishing the site-selective (mono) γ-C(sp2)−H arylation in substrates containing competitive C(sp3)−H and C(sp2)−H bonds. The investigation has enabled to assemble a library of pyridine-N-oxide-based biarylacetamides, heteroaryl-based biaryl carboxamides, tricyclic quinolones, arylheteroarylmethanes, biaryl-based aliphatic carboxamides and mono (ortho) arylated phenylglycine derivatives. In general, biaryl derivatives and in particular, arylacetamide, arylacetic acid derivatives and pyridine-N-oxide (2-aminopyridyl) motifs are medicinally relevant classes of compounds. This work enabled the assembling of a library of the above-mentioned types of compounds through the pyridine-N-oxide directing group-aided site-selective sp2/sp3 γ-C−H and sp2 δ-C−H functionalization of carboxamides. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | Wiley | en_US |
dc.subject | Pyridine-N-oxide | en_US |
dc.subject | Carboxamides | en_US |
dc.title | Expanding the Utility of Inexpensive Pyridine-N-oxide Directing Group for the Site-selective sp2/sp3 γ-C−H and sp2 δ-C−H Functionalization of Carboxamides | en_US |
dc.type | Article | en_US |
Appears in Collections: | Research Articles |
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