Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/4760
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dc.contributor.authorAggarwal, Yashika-
dc.contributor.authorPadmavathi, Rayavarapu-
dc.contributor.authorSingh, Prabhakar-
dc.contributor.authorArulananda Babu, Srinivasarao-
dc.date.accessioned2023-08-17T05:22:52Z-
dc.date.available2023-08-17T05:22:52Z-
dc.date.issued2022-
dc.identifier.citationAsian Journal of Organic Chemistry, 11(9), 2200327en_US
dc.identifier.urihttps://doi.org/10.1002/ajoc.202200327-
dc.identifier.urihttp://hdl.handle.net/123456789/4760-
dc.descriptionOnly IISERM authors are available in the recorden_US
dc.description.abstractThis paper reports the synthesis of enantiopure aryl alkyl ethers via the Pd(II)-catalyzed picolinamide-aided γ-C(sp2)−H alkoxylation of various enantiopure α-alkylbenzylamine derivatives using alcohols. Enantiopure α-methylbenzylamines and amino alcohol substrates such as 2-amino-2-phenylethanol (phenylglycinol) and 3-amino-3-phenylpropanol were subjected to the γ-C(sp2)−H alkoxylation (etherification) with alcohols using PIDA. α-Alkylbenzylamines and phenylglycinols are valuable building blocks in organic synthesis and medicinal chemistry research areas. Accordingly, this work has enabled the assembling of various enantiopure ortho-alkoxylated α-methylbenzylamine and 2-amino-2-phenylethanol (phenylglycinol) and 3-amino-3-phenylpropanol derivatives containing aryl alkyl ether functionality. We have shown the utility of ortho-alkoxylated α-methylbenzylamine derivatives for assembling enantiopure α-methylbenzylamine-based sulfamoylcarbamates and carboxamides which are structurally related to the bio-active compounds known in the literature. This work demonstrates the substrate scope elaboration in C−H functionalization and etherification through the C−O bond-forming process and synthesis of aryl alkyl ether functionality containing enantiopure α-alkylbenzylamines.en_US
dc.language.isoen_USen_US
dc.publisherWileyen_US
dc.subjectAlkoxylationen_US
dc.subjectα-Methylbenzylamineen_US
dc.subjectAryl Alkyl Ethersen_US
dc.titlePd(II)-Catalyzed, γ-C(sp2)−H Alkoxylation in α-Methylbenzylamine, Phenylglycinol, 3-Amino-3-Phenylpropanol Toward Enantiopure Aryl Alkyl Ethersen_US
dc.typeArticleen_US
Appears in Collections:Research Articles

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