Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/4794
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dc.contributor.authorRai, Sandeep K-
dc.contributor.authorMukhopadhyay, Samrat-
dc.date.accessioned2023-08-17T16:10:48Z-
dc.date.available2023-08-17T16:10:48Z-
dc.date.issued2022-
dc.identifier.citationBiophysical Journal, 121(20), 3768-3770.en_US
dc.identifier.urihttps://doi.org/10.1016/j.bpj.2022.08.043-
dc.identifier.urihttp://hdl.handle.net/123456789/4794-
dc.descriptionOnly IISERM authors are available in the recorden_US
dc.description.abstractLiving cells are enriched with fluidic materials that are full of activity. Biomolecules such as proteins, lipids, and nucleic acids, as well as small regulatory molecules like ATP, need to be organized and regulated in such a crowded milieu to perform cellular functions. Cells achieve this functional coherence by compartmentalizing their constituents into membrane-bound organelles. Intense research over the past decade has revealed that cells can also accomplish intracellular compartmentalization using membrane-less organelles or biomolecular condensates that aren formed via phase separation of proteins and nucleic acids (1). These noncanonical organelles include P bodies, stress granules, Cajal bodies, nucleoli, and others. Unlike membrane-bound organelles, these on-demand, liquid-like, highly dynamic biomolecular condensates lack the membrane barrier and are susceptible to modest perturbations in their local environment, making them tunable, permeable, and regulatable. The principal governing forces for forming these condensates are weak, noncovalent, transient, and multivalent interactions between flexible biopolymers such as intrinsically disordered proteins/regions and nucleic acids (2–4).en_US
dc.language.isoen_USen_US
dc.publisherElsevieren_US
dc.subjectnucleolar condensatesen_US
dc.subjectTuning material propertiesen_US
dc.titleSmall molecules playing big roles: Tuning material properties of nucleolar condensatesen_US
dc.typeArticleen_US
Appears in Collections:Research Articles

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