Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/4949
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dc.contributor.authorPani, Ipsita-
dc.contributor.authorK. M., Fidha Nazreen-
dc.contributor.authorSharma, Monika-
dc.contributor.authorPal, Santanu Kumar-
dc.date.accessioned2023-08-21T09:26:17Z-
dc.date.available2023-08-21T09:26:17Z-
dc.date.issued2021-
dc.identifier.citationNano Letters, 21(11), 4546–4553.en_US
dc.identifier.urihttps://pubs.acs.org/doi/10.1021/acs.nanolett.0c05139-
dc.identifier.urihttp://hdl.handle.net/123456789/4949-
dc.descriptionOnly IISERM authors are available in the record.en_US
dc.description.abstractAqueous interfaces of liquid crystals (LCs) are widely explored in the design of functional interfaces to recapitulate the key aspects of biomolecular interactions in cellular milieu. Herein, using aqueous LC dispersions, we explore the interactions between mitochondrial cardiolipin and membrane-associated cytochrome c which play a pivotal role in the apoptotic signaling cascade. Conventional techniques used to decipher LC ordering at the droplet interface fail to give information about the interactions at a molecular level. Besides, owing to the complexity of LC systems and multiple determinants driving the LC reorientation, accurate analysis of the underlying mechanism responsible for the LC ordering transition remains challenging. Using a combination of atomistic simulations and microscopic and spectroscopic readouts, for the first time, we unveil the lipid–protein interactions that drive the reorientation at the LC droplet interface. The insights from our work are fundamental to the design of these interfaces for a spectrum of interfacial applications.en_US
dc.language.isoen_USen_US
dc.publisherACS Publicationsen_US
dc.subjectlipid−protein interactionen_US
dc.subjectlipid−protein interactionen_US
dc.titleProbing Nanoscale Lipid–Protein Interactions at the Interface of Liquid Crystal Dropletsen_US
dc.typeArticleen_US
Appears in Collections:Research Articles

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