Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/4991
Full metadata record
DC FieldValueLanguage
dc.contributor.authorChoudhury, Angshuman Roy-
dc.date.accessioned2023-08-21T16:02:25Z-
dc.date.available2023-08-21T16:02:25Z-
dc.date.issued2022-
dc.identifier.citationDalton Transactions, 51(42), 16371- 16382.en_US
dc.identifier.urihttps://doi.org/10.1039/d2dt02577a-
dc.identifier.urihttp://hdl.handle.net/123456789/4991-
dc.descriptionOnly IISER Mohali authors are available in the record.en_US
dc.description.abstractThe chemotherapeutic potential of ruthenium(II) complexes has recently attracted researchers’ interest as antibacterial and anticancer agents. In this study, two novel half-sandwich imine-based Ru complexes ([Ru(p-cymene)Cl(L-1)][PF6] (Ru-1) and [Ru(p-cymene)Cl(L-2)][PF6] (Ru-2)) were reported for their deoxyribonucleic acid (DNA) binding and antitubercular, antibacterial, and anticancer activities. The molecular structure of Ru-2 was obtained by single-crystal X-ray crystallography. DNA interaction studies were conducted by UV-Vis absorbance and fluorescence spectral titration which gave rise to DNA binding constants (Kb) of 1.32 × 106 and 1.82 × 106 for Ru-1 and Ru-2, respectively and the Stern–Volmer binding constant (KSV) values for Ru-1 and Ru-2 were 1.7763 × 104 M−1 and 7.6 × 103 M−1, respectively. The in vitro antitubercular activity was evaluated against Mycobacterium tuberculosis H37Ra. The antibacterial potential of both the Ru-complexes was examined against Gram-negative (Escherichia coli and Pseudomonas aeruginosa) and Gram-positive (Staphylococcus aureus and Bacillus subtilis) bacteria. The half-maximal inhibitory concentration (IC50) values for the antitubercular activity of Ru-1 and Ru-2 were 4.87 ± 1.32 μM and 5.78 ± 0.54 μM, respectively. A cytotoxic study of these complexes was performed against the human breast cancer cell line (MCF-7) and the human embryonic kidney cell line (HEK293) (normal cells). The study revealed meaningful activity of the Ru-1 complex against (cancer) MCF-7 cells, while the viability of HEK293 (normal) cells in the presence of Ru-2 was higher as compared to a reference drug 5FU. We suggest that these kinds of Ru-complexes could have potential for application in metallopharmaceuticals.en_US
dc.language.isoen_USen_US
dc.publisherRoyal Society of Chemistryen_US
dc.subjectDNA binding, antibacterialen_US
dc.subjectpiano-stool ruthenium(ii) complexesen_US
dc.subjectantitubercular,en_US
dc.titleDNA binding, antitubercular, antibacterial and anticancer studies of newly designed piano-stool ruthenium(ii) complexesen_US
dc.typeArticleen_US
Appears in Collections:Research Articles

Files in This Item:
File Description SizeFormat 
Need To Add…Full Text_PDF.15.36 kBUnknownView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.