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http://hdl.handle.net/123456789/5154
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DC Field | Value | Language |
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dc.contributor.author | Bisht, Narendra | - |
dc.contributor.author | Singh, Prabhakar | - |
dc.contributor.author | Babu, Srinivasarao Arulananda | - |
dc.date.accessioned | 2023-08-24T08:01:20Z | - |
dc.date.available | 2023-08-24T08:01:20Z | - |
dc.date.issued | 2022 | - |
dc.identifier.citation | Synthesis (Germany), 54(18), 4059-4094. | en_US |
dc.identifier.uri | https://doi.org/10.1055/a-1830-3962 | - |
dc.identifier.uri | http://hdl.handle.net/123456789/5154 | - |
dc.description | Only IISER Mohali authors are available in the record. | en_US |
dc.description.abstract | In this paper, we report the Pd(II)-catalyzed, picolinamide DG-aided sp2 γ-C–H functionalization and expansion of the library of enantiopure α-methylbenzylamine and phenylglycinol scaffolds. We have shown the synthesis of a wide range of racemic and enantiopure ortho-C–H arylated, alkylated, brominated, and iodinated α-methylbenzylamine and phenylglycinol scaffolds. Various racemic and R and S (chiral) sp2 γ-C–H functionalized α-methylbenzylamine and phenylglycinol scaffolds were synthesized with good enantiopurities. Racemic and enantiopure α-methylbenzylamine and phenylglycinol derivatives are important building blocks in organic synthesis and medicinal chemistry. Accordingly, this work contributes to the expansion of the libraries of α-methylbenzylamine and phenylglycinol motifs and substrate scope development through the Pd(II)-catalyzed bidentate directing group picolinamide-aided site-selective C–H activation and functionalization method. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | Thieme | en_US |
dc.subject | Picolinamide-Aided | en_US |
dc.subject | Functionalization of Racemic | en_US |
dc.subject | α-Methylbenzylamine | en_US |
dc.subject | Phenylglycinol Scaffolds | en_US |
dc.title | Pd(II)-Catalyzed, Picolinamide-Aided γ-(sp2)-C–H Functionalization of Racemic and Enantiopure α-Methylbenzylamine and Phenylglycinol Scaffolds | en_US |
dc.type | Article | en_US |
Appears in Collections: | Research Articles |
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