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DC Field | Value | Language |
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dc.contributor.author | Singh, Gurdeep | - |
dc.date.accessioned | 2023-11-25T17:58:18Z | - |
dc.date.available | 2023-11-25T17:58:18Z | - |
dc.date.issued | 2023-01-27 | - |
dc.identifier.uri | http://hdl.handle.net/123456789/5328 | - |
dc.description.abstract | Oxygen and nitrogen-containing heterocycles such as benzo[b]furan, dihydrobenzofuran, coumarins, chromenes, and carbazoles are important scaffolds and widely found in many natural products and biologically active molecules, and several of them display various impressive pharmacological activities such as anti-cancer, anti-allergic, anti-HIV, cytotoxic, etc. Due to their fascinating and diverse range of applications in material science as well, numerous synthetic techniques have been documented to access these heterocycles, but most of them require pre-functionalized starting material(s), poor substrate scope, lack of regioselectivity, and an expensive metal catalyst. Therefore, developing practical and metal- free protocols to access these derivatives is highly desirable and advantageous. In the recent past, para-quinone methide chemistry has been widely explored for the synthesis of various organic frameworks such as heterocycles, carbocycles, spiro-cycles, etc. In the present work, we have utilized the para-quinone methides (p-QMs) as a 1,6-conjugate acceptor for the synthesis of oxygen and nitrogen-containing heterocycles under metal-free reaction conditions. The first chapter of this work involves the synthesis of 2,3-diaryl benzo[b]furans, dihydrobenzofurans, 3,4-diaryl coumarins, and chromenes by the reaction of 2-hydroxyphenyl substituted para-quinone methides with suitable coupling partners under acidic/basic conditions. The second chapter describes the [3+3] annulation of 2- indolylmethanols with para-quinone methides for the formation of tetrahydroindolo[2,3- b]carbazoles. Further, this work has been extended to synthesize different isomers of tetrahydrothieno carbazoles. | en_US |
dc.language.iso | en | en_US |
dc.publisher | IISER Mohali | en_US |
dc.subject | Para-Quinone | en_US |
dc.subject | Oxygen | en_US |
dc.subject | Heterocycles | en_US |
dc.title | Metal-free Transformations of para-Quinone Methides (p-QMs) to Oxygen-Containing Heterocycles and Carbazoles | en_US |
dc.type | Thesis | en_US |
dc.guide | Anand, R. Vijaya | en_US |
Appears in Collections: | PhD-2017 |
Files in This Item:
File | Description | Size | Format | |
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Full thesis.pdf | 20.02 MB | Adobe PDF | View/Open |
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