Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/5693
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dc.contributor.authorKaushal, Shashwat-
dc.date.accessioned2025-02-28T10:23:21Z-
dc.date.available2025-02-28T10:23:21Z-
dc.date.issued2024-05-
dc.identifier.urihttp://hdl.handle.net/123456789/5693-
dc.descriptionUnder Embargo Perioden_US
dc.description.abstractPiwi-interacting RNAs (piRNAs) are small, non-coding RNA molecules known to perform epigenetic and post-transcriptional silencing of the transposable elements. Biogenesis of piRNAs, generally, involves two mechanisms known as "phasing" and "ping-pong cycle". These mechanisms are conserved in most of the existing species. The absence of one of these negatively affects the species' fitness due to transposon overexpression that can lead to genome instability, change in epigenetic landscape and/or loss of fertility. Drosophila eugracilis lacks the "ping-pong cycle" mode of biogenesis, but does not face the abovementioned challenges. It produces primarily antisense piRNAs to partly compensate for the absence of "ping-pong cycle", but the mechanism is still not completely understood. The study is mainly focused on contributing to setting up Drosophila eugracilis as a model organism and understanding the transcriptional and evolutionary basis of piRNA biogenesis. This involves the generation of high-quality piRNA libraries and genome assemblies and analysing the interaction of transcription machinery with the piRNA clusters in different strains of Drosophila eugracilis. Further, the study provides some preliminary insights into the evolution of antisense sense bias of piRNA biogenesis in Drosophila eugracilis.en_US
dc.language.isoenen_US
dc.publisherIISER Mohalien_US
dc.subjectDrosophila Familyen_US
dc.subjectFly husbandryen_US
dc.subjectTransposable Elementen_US
dc.titleTranscriptional and evolutionary basis of piRNA mediated transposon silencing in Drosophila eugracilisen_US
dc.typeThesisen_US
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