Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/573
Title: CREB Regulates Expression of Neuropeptide FLP-18 and Controls Backward Movement
Authors: Thapliyal, Saurabh
Keywords: Biology
CREB
C.elegans
Genes
Neuropeptide
Issue Date: 8-Aug-2016
Publisher: IISER-M
Abstract: CREB is a transcription factor. CREB is known to regulate expression of various genes involved in different functions. We found that CREB regulates expression of neuropeptide FLP-18 in C.elegans. FLP-18 is known to effect backward movement in C.elegans. Further we go on to show that CREB controls length of backward movement in C.elegans. Mutation in CREB homolog crh-1 resulted in decreased length of backward movement. This phenotype was rescued by expressing repressor isoform of CREB, CRH-1f in crh-1 mutants. These results suggests that CREB regulate FLP-18 expression and length of backward movement during exploratory behavior in C.elegans
URI: http://hdl.handle.net/123456789/573
Appears in Collections:MS-11

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